Manipulation of environmental oxygen modifies reactive oxygen and nitrogen species generation during myogenesis

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Manipulation of environmental oxygen modifies reactive oxygen and nitrogen species generation during myogenesis

Regulated changes in reactive oxygen and nitrogen species (RONS) activities are important in maintaining the normal sequence and development of myogenesis. Both excessive formation and reduction in RONS have been shown to affect muscle differentiation in a negative way. Cultured cells are typically grown in 20% O2 but this is not an appropriate physiological concentration for a number of cell t...

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ژورنال

عنوان ژورنال: Redox Biology

سال: 2016

ISSN: 2213-2317

DOI: 10.1016/j.redox.2016.01.011